noninvasive bi-pap therapy system Search Results


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Respironics noninvasive ventilatory support bipap
Noninvasive Ventilatory Support Bipap, supplied by Respironics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Respironics bi-pap s/t-d ventilatory support system
Bi Pap S/T D Ventilatory Support System, supplied by Respironics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Respironics v60 bi-pap ventilator
V60 Bi Pap Ventilator, supplied by Respironics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Institut Curie bi-pap technique
Bi Pap Technique, supplied by Institut Curie, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Respironics bi-pap® s/t ventilator
Bi Pap® S/T Ventilator, supplied by Respironics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Respironics auto bi-pap (nasal)
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Auto Bi Pap (Nasal), supplied by Respironics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Agilent technologies mx3005p
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Mx3005p, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Respironics bipap bipap® auto-m series
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Bipap Bipap® Auto M Series, supplied by Respironics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Respironics bipap
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Bipap, supplied by Respironics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Philips Healthcare bipap avaps 30
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Bipap Avaps 30, supplied by Philips Healthcare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Carefusion bipap sipap
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Bipap Sipap, supplied by Carefusion, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Respironics respironics bipap harmony
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Respironics Bipap Harmony, supplied by Respironics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Table of devices

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Table of devices

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Titration

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 4 Quality of life (Functional Outcomes of Sleep Questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 4 Quality of life (Functional Outcomes of Sleep Questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison, Functional Assay

Summary of study and participant characteristics at baseline

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Summary of study and participant characteristics at baseline

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques:

 Auto‐CPAP  compared to fixed CPAP for sleep apnoea in adults

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Auto‐CPAP compared to fixed CPAP for sleep apnoea in adults

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Biomarker Discovery, Comparison, Functional Assay

Bi‐PAP compared to fixed  CPAP  for sleep apnoea in adults

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Bi‐PAP compared to fixed CPAP for sleep apnoea in adults

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Biomarker Discovery, Comparison, Functional Assay

 CPAP  with expiratory pressure relief compared to fixed  CPAP  for adults with obstructive sleep apnoea

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: CPAP with expiratory pressure relief compared to fixed CPAP for adults with obstructive sleep apnoea

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Biomarker Discovery, Comparison, Functional Assay

Heated humidification + fixed  CPAP  compared to fixed  CPAP  alone in adults with obstructive sleep apnoea

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Heated humidification + fixed CPAP compared to fixed CPAP alone in adults with obstructive sleep apnoea

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Biomarker Discovery, Comparison, Functional Assay

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Forest plot of comparison: 1 Auto‐CPAP versus fixed CPAP, outcome: 1.1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Forest plot of comparison: 1 Auto‐CPAP versus fixed CPAP, outcome: 1.1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 2 Machine usage (hours/night) (Pepin imputed).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 2 Machine usage (hours/night) (Pepin imputed).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 3 Number of participants who used CPAP therapy > 4 hours per night.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 3 Number of participants who used CPAP therapy > 4 hours per night.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 4 Machine usage (on nights when CPAP used 'effectively').

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 4 Machine usage (on nights when CPAP used 'effectively').

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 5 Machine usage (frequency of usage as % of days).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 5 Machine usage (frequency of usage as % of days).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 6 Machine usage (% of nights of > 4 hours of use) ‐ cross‐over studies.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 6 Machine usage (% of nights of > 4 hours of use) ‐ cross‐over studies.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 7 Symptoms (Epworth Sleepiness Scale).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 7 Symptoms (Epworth Sleepiness Scale).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 8 Withdrawals (parallel group trials/first arm cross‐over trials).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 8 Withdrawals (parallel group trials/first arm cross‐over trials).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 9 Quality of life (Functional Outcomes of Sleep Questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 9 Quality of life (Functional Outcomes of Sleep Questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison, Functional Assay

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 10 Quality of life (Sleep Apnoea Quality of Life Index).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 10 Quality of life (Sleep Apnoea Quality of Life Index).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 11 Quality of life (SF‐36 questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 11 Quality of life (SF‐36 questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 12 Apnoea Hypopnoea Index (events/hr).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 12 Apnoea Hypopnoea Index (events/hr).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 13 Arousals (events/hr).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 13 Arousals (events/hr).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 14 Pressure of CPAP treatment (cmH2O).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 14 Pressure of CPAP treatment (cmH2O).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 15 Systolic blood pressure.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 15 Systolic blood pressure.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 16 Diastolic blood pressure.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 16 Diastolic blood pressure.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 17 24‐hour mean BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 17 24‐hour mean BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 18 24‐hour systolic BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 18 24‐hour systolic BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 19 24‐hour diastolic BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 19 24‐hour diastolic BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 20 Diurnal mean BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 20 Diurnal mean BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 21 Diurnal systolic BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 21 Diurnal systolic BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 22 Diurnal diastolic BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 22 Diurnal diastolic BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 23 Nocturnal mean BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 23 Nocturnal mean BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 24 Nocturnal systolic BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 24 Nocturnal systolic BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 25 Nocturnal diastolic BP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 25 Nocturnal diastolic BP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 26 Tolerability outcomes.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 26 Tolerability outcomes.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Forest plot of comparison: 2 Bi‐PAP versus fixed CPAP, outcome: 2.1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Forest plot of comparison: 2 Bi‐PAP versus fixed CPAP, outcome: 2.1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 3 Withdrawals (parallel group trials/first arm cross‐over trials).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 3 Withdrawals (parallel group trials/first arm cross‐over trials).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 5 Quality of life (Sleep Apnoea Quality of Life Index).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 5 Quality of life (Sleep Apnoea Quality of Life Index).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 6 Quality of life (SF‐36 questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 6 Quality of life (SF‐36 questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 7 Apnoea Hypopnoea Index (events/hr).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 7 Apnoea Hypopnoea Index (events/hr).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 9 Tolerability outcomes.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 9 Tolerability outcomes.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Forest plot of comparison: 3 CPAP with expiratory pressure relief versus fixed CPAP, outcome: 3.1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Forest plot of comparison: 3 CPAP with expiratory pressure relief versus fixed CPAP, outcome: 3.1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 3 Withdrawals (parallel group trials/first arm cross‐over trials).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 3 Withdrawals (parallel group trials/first arm cross‐over trials).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 4 Quality of life (Functional Outcomes of Sleep Questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 4 Quality of life (Functional Outcomes of Sleep Questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison, Functional Assay

Comparison 3 CPAPexp versus fixed CPAP, Outcome 5 Quality of life (SF‐36 questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 5 Quality of life (SF‐36 questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 6 Apnoea Hypopnoea Index (events/hr).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 6 Apnoea Hypopnoea Index (events/hr).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 7 Pressure of CPAP treatment (cmH2O).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 7 Pressure of CPAP treatment (cmH2O).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 8 Treatment satisfaction score.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 8 Treatment satisfaction score.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 9 Treatment comfort score.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 9 Treatment comfort score.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 10 Treatment interface score.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 10 Treatment interface score.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Forest plot of comparison: 4 Heated humidification + fixed pressure CPAP versus fixed pressure CPAP alone, outcome: 4.1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Forest plot of comparison: 4 Heated humidification + fixed pressure CPAP versus fixed pressure CPAP alone, outcome: 4.1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 5 Quality of life (SF‐36 questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 5 Quality of life (SF‐36 questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 4 Apnoea Hypopnoea Index (events/hr).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 4 Apnoea Hypopnoea Index (events/hr).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 6 Nasal symptoms (parallel group trials).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 6 Nasal symptoms (parallel group trials).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 7 Nasal symptoms (parallel group trials).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 7 Nasal symptoms (parallel group trials).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 3 Withdrawals (parallel group trials/first arm cross‐over trials).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 3 Withdrawals (parallel group trials/first arm cross‐over trials).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 4 Quality of life (Functional Outcomes of Sleep Questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 4 Quality of life (Functional Outcomes of Sleep Questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison, Functional Assay

Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 5 Apnoea Hypopnoea Index (events/hr).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 5 Apnoea Hypopnoea Index (events/hr).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 6 Pressure of CPAP treatment (cmH2O).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 6 Pressure of CPAP treatment (cmH2O).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 7 Systolic blood pressure.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 7 Systolic blood pressure.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 8 Diastolic blood pressure.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 5 Auto‐CPAPexp versus fixed CPAP, Outcome 8 Diastolic blood pressure.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 6 Bi‐PAPexp versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 6 Bi‐PAPexp versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 6 Bi‐PAPexp versus fixed CPAP, Outcome 2 Number of participants who used CPAP therapy > 4 hours per night.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 6 Bi‐PAPexp versus fixed CPAP, Outcome 2 Number of participants who used CPAP therapy > 4 hours per night.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 2 Number of participants who used CPAP therapy > trialist defined threshold.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 2 Number of participants who used CPAP therapy > trialist defined threshold.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 3 Symptoms (Epworth Sleepiness Scale).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 3 Symptoms (Epworth Sleepiness Scale).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 4 Withdrawals.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 4 Withdrawals.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 5 Quality of life (Functional Outcomes of Sleep Questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 5 Quality of life (Functional Outcomes of Sleep Questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison, Functional Assay

Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 6 Apnoea Hypopnoea Index (events/hr).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 7 Auto Bi‐PAP versus fixed CPAP, Outcome 6 Apnoea Hypopnoea Index (events/hr).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 1 Machine usage (hours/night).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 27 Patient preference (auto‐CPAP/not auto‐CPAP).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 1 Auto‐CPAP versus fixed CPAP, Outcome 27 Patient preference (auto‐CPAP/not auto‐CPAP).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 2 Symptoms (Epworth Sleepiness Scale).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 8 Patient preference ‐ BiPAP/no preference or CPAP.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 8 Patient preference ‐ BiPAP/no preference or CPAP.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 10 Treatment comfort score.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 2 Bi‐PAP versus fixed CPAP, Outcome 10 Treatment comfort score.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 3 CPAPexp versus fixed CPAP, Outcome 11 Preference.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 3 CPAPexp versus fixed CPAP, Outcome 11 Preference.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 4 Apnoea Hypopnoea Index (events/hr).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 4 Apnoea Hypopnoea Index (events/hr).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 8 Preference.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 4 Heated humidification + fixed CPAP versus fixed CPAP alone, Outcome 8 Preference.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 3 Quality of life (Functional Outcomes of Sleep Questionnaire).

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 3 Quality of life (Functional Outcomes of Sleep Questionnaire).

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison, Functional Assay

Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 5 Mask leak.

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Comparison 8 CPAPexp with wakefulness detection versus fixed CPAP, Outcome 5 Mask leak.

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Comparison

 Auto‐CPAP  versus fixed CPAP

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Auto‐CPAP versus fixed CPAP

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Functional Assay

Bi‐PAP versus fixed  CPAP

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Bi‐PAP versus fixed CPAP

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Functional Assay

CPAPexp versus fixed  CPAP

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: CPAPexp versus fixed CPAP

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Functional Assay

Heated humidification + fixed  CPAP  versus fixed  CPAP  alone

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Heated humidification + fixed CPAP versus fixed CPAP alone

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques:

Auto‐CPAPexp versus fixed  CPAP

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Auto‐CPAPexp versus fixed CPAP

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Functional Assay

Bi‐PAPexp versus fixed  CPAP

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Bi‐PAPexp versus fixed CPAP

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques:

Auto Bi‐PAP versus fixed  CPAP

Journal: The Cochrane Database of Systematic Reviews

Article Title: Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

doi: 10.1002/14651858.CD003531.pub4

Figure Lengend Snippet: Auto Bi‐PAP versus fixed CPAP

Article Snippet: Age: 55 years; BMI: 33 kg/m 2 ; ESS: 9 Inclusion criteria : 21 to 75 years; AHI > 15; suboptimal CPAP titration after at least 3 hours of attempted titration Exclusion criteria : major medical or psychiatric illness; chronic respiratory failure; upper airway/ENT surgery in last 90 days; shift workers; alcohol/drug abuse within last three years; hypnotic use < 3 months; PLMI > 10 per hour; complex/central sleep apnoea; CPAP contraindication Interventions Auto bi‐PAP (nasal) versus fixed CPAP Study duration: 90 days Outcomes Machine usage (average hours used and N using it effectively) Symptoms (ESS and Fatigue Severity Scale) Quality of life (FOSQ) Withdrawals Funding & conflicts of interest statements Quote: "This study was supported by a grant from Phillips Respironics.

Techniques: Functional Assay